Treatments for multiple myeloma can impact your ability to have children (fertility).^1-8 This article will summarise how these treatments can affect fertility and how your healthcare team can help you if you do want to start a family.

Some useful definitions are provided below:

• Breastfeeding: Feeding a child human breast milk⁹
• Hormone: Chemical messengers in the body^10,11
• Testosterone: A hormone that is important for sex drive and getting an erection in men¹¹
• Uterus: A part of the female reproductive system where babies develop^10,12 

1. What is fertility? ^10,11

Fertility is the ability to have children (conceive). For men this is the ability to start a pregnancy (when a sperm fertilizes an egg), and for women this is the ability to get pregnant and give birth to a baby. In both men and women, several parts of the body work together to achieve this – collectively these parts of the body are called the reproductive system. Some multiple myeloma treatments can change how you feel about sex, and some can affect the reproductive system directly. All these changes affect your fertility.

2. Fertility in women 

Some multiple myeloma treatments may cause infertility.^1-8 Infertility means that you can’t get pregnant.¹ Your healthcare team will advise you on the potential risks to your fertility before they give you your treatment.¹⁰ You can speak to your healthcare team about having your fertility tested after you finish cancer treatment.¹³ 

Different multiple myeloma treatments can cause different levels of infertility: 

• Temporary infertility is when your period may become irregular or stop during treatment but will go back to normal when the treatment is over. It usually takes between 6 and 12 months for your period to get back to normal¹
• Permanent infertility is more likely when receiving higher drug doses. It is also more likely in older women, because they are closer to the age of natural menopause¹
• Early menopause. Menopause is when the ovaries completely stop producing the hormones needed for fertility (reproductive hormones).¹⁴ During early menopause, periods become irregular and stop, accompanied by symptoms such as hot flushes, dry skin, vaginal dryness, loss of energy, less interest in sex, mood swings, and low mood¹

Treatment for multiple myeloma can affect fertility in different ways, for example:

• Chemotherapy uses anti-cancer drugs to destroy cancer cells.¹⁵ It can also reduce the number of eggs stored in the ovaries or make your body release fewer or no eggs. This may cause temporary infertility, permanent infertility or early menopause¹⁰
• Radiotherapy uses high-energy rays to destroy cancer cells. These can also damage the ovaries or eggs, uterus, or pituitary gland (all part of the reproductive system). The effect on fertility is dependent on the dose of radiotherapy and your age
• Total body irradiation is radiotherapy given to the whole body before a bone marrow or a donor stem cell transplant. This usually causes permanent infertility¹⁰
• Targeted therapy and immunotherapy drugs kill cancer cells, either directly or by using the immune system.¹⁰ The effects of these drugs on fertility can vary depending on how each drug works, but many may reduce fertility^1-8

You can talk to your healthcare team about how your fertility may be affected by multiple myeloma treatment. They may refer you to a fertility clinic before cancer treatment is started. The fertility clinic will be able to talk about options that could allow you to have a baby in the future and discuss different ways of preserving your fertility. For example, they could suggest freezing your eggs or embryos, which can later be thawed and put into your uterus if you do decide to try to get pregnant.13 You may also be offered hormone treatment which temporarily stops your ovaries from working (ovarian suppression) during multiple myeloma treatment. This may protect your ovaries from the harmful effects of treatment and help to preserve your fertility.¹⁶  
 

3. Fertility in men 

As in women, multiple myeloma treatment can cause infertility in men. This can be temporary or permanent and will depend on the drugs used, the dose taken, and the age of the person being treated.¹⁷ In men it can be difficult to tell whether the infertility is permanent or not.¹⁶ Your healthcare team will advise you on the potential risks to your fertility before they give you your treatment.¹¹ To check your fertility, your healthcare team can do regular sperm counts for you when the treatment is over.¹⁷

Treatment for multiple myeloma can affect male fertility in different ways, for example:

• Chemotherapy uses anti-cancer drugs to destroy cancer cells.¹¹ It can slow down or stop sperm production^11,17
• Radiotherapy uses high-energy rays to destroy cancer cells.¹¹ Depending on where in the body it is targeted, it can affect sperm production and erections, and also reduce the levels of testosterone^11,13
• Total body irradiation is radiotherapy given to the whole body before a bone marrow or a donor stem cell transplant. This usually causes permanent infertility¹¹
• Targeted therapy and immunotherapy drugs kill cancer cells, either directly or by using the immune system.¹¹ The effects of these drugs on fertility can vary depending on how each drug works, but many may reduce fertility^1-8

Before starting your multiple myeloma treatment, you can talk to your healthcare team about fertility. They may refer you to a fertility clinic before any treatment is started. Your fertility doctor can talk to you about fertility treatments that may help. They may advise you to consider “sperm banking”. This is the process of freezing and storing your sperm, which can be used in the future to help you and a partner try to have a baby.^11,17

4. Multiple myeloma treatment during and after pregnancy 

There is a risk that some multiple myeloma treatments may cause harm to the developing fetus, and therefore cannot be used during pregnancy.^{2-8, 18-23} Your healthcare team will discuss any risk with you before starting treatment, and both you and your baby will be carefully monitored throughout the course of your treatment.²⁴

Chemotherapy can usually be given after you are 14 weeks into the pregnancy, but before this time it is not recommended as there is potential to harm the developing baby or cause a miscarriage. Sometimes chemotherapy can be delayed until the baby is born, but this may not always be possible.²⁴ 

There is also a risk that some multiple myeloma treatments may be passed on to your baby through your breast milk. Your healthcare team will advise you about breastfeeding.²⁵

For women of a reproductive age, your healthcare team may advise you to use a suitable form of contraception to prevent pregnancy during multiple myeloma treatment.26 Your healthcare team will discuss all your available options and help you to reach a decision that is right for you.²⁴ 

 

5. Getting help and support
It can be very difficult to learn that your multiple myeloma treatment may lead to infertility. It can help to speak to your family and friends about your feelings and worries. Your healthcare team is also there to support you, and they may be able to refer you to a counselor or specialist nurse who can offer more guided support.²⁷

There are also support groups available should you wish to seek help in this way.²⁸
 

References

1. Cancer Research UK. How Chemotherapy Affects Women’s Fertility. Available here. Accessed 01 March 2023. 
2. Belantamab Prescribing Information. Revised August, 2020. Accessed October 24, 2022.
3. Bortezomib Prescribing Information. Revised November, 2021. Accessed October 24, 2022.
4. Panobinostat Prescribing Information. Revised February, 2015. Accessed October 24, 2022.
5. Pomalidomide Prescribing Information. Revised October, 2021. Accessed October 24, 2022.
6. Selinexor Prescribing Information. Revised July, 2019. Accessed October 24, 2022.
7. Thalidomide Prescribing Information. Revised June, 2019. Accessed October 24, 2022.
8. Venetoclax Prescribing Information. Revised April, 2016. Accessed October 24, 2022.
9. MedicineNet. Medical Definition of Breastfeeding. Available here. Accessed 01 March 2023
10. Macmillan Cancer Support. Fertility in Women. Available here. Accessed 01 March 2023.
11. Macmillan Cancer Support. Fertility in Men. Available here. Accessed 01 March 2023.
12. Cleveland Clinic. Uterus. Available here. Accessed 01 March 2023. 
13. NHS Inform. Fertility. Available here. Accessed 01 March 2023. 
14. Cancer Research UK. Menopausal symptoms and cancer treatment. Available here. Accessed 01 March 2023.
15. Cancer Research UK. First Treatment for Myeloma. Available here. Accessed 01 March 2023.
16. Cancer Research UK. Ways to preserve your fertility. Available here. Accessed 01 March 2023.
17. Cancer Research UK. Men’s Fertility and Chemotherapy. Available here. Accessed 01 March 2023.
18. University of Rochester Medical Center. Multiple Myeloma: Chemotherapy and Other Medicines. Available here. Accessed 01 March 2023. 
19. Carfilozimib Prescribing Information. Revised July 2012.
20. Isatuximab Prescribing Information. Revised March, 2020.
21. Ixazomib Prescribing Information. Revised April, 2022.
22. Lenalidomide Prescribing Information. Revised June, 2013.
23. Cilta-cel Prescribing Information. Revised February, 2022.
24. Cancer Research UK. Being Pregnant at Diagnosis. Available here. Accessed 01 March 2023.
25. Macmillan Cancer Support. Breastfeeding and cancer treatments. Available here. Accessed 01 March 2023.
26. Cancer Research UK. Pregnancy and Contraception. Available here. Accessed 01 March 2023.
27. Cancer Research UK. Coping With Infertility. Available here. Accessed 01 March 2023. 
28. Cancer Research UK. What You Can Do to Help Yourself. Available  here. Accessed 01 March 2023.